A circulatory light source enabled by trap-engineered phosphors
Infrared neural modulation with semiconducting polymers
Tissue modulation with nanoantennas and free-space radio waves
Bioinspired synthesis of water-soluble solid-state nanophosphors
"We are developing a circulation-delivered internal light source for biomedical applications that need light emission deep inside the body, such as optogenetics, fluorescence imaging, and photodynamic therapy. We leverage the demonstrated deep-brain penetration of NIR-II light (1000-1700 nm) to develop infrared optogenetics based on bandgap-engineered semiconducting polymers. We are developing injectable nanoantennas and radiofrequency (RF) generators to modulate and communicate with the biological tissue with free-space radio waves. We are developing a bioinspired approach to synthesize solid-state ceramic phosphors with nanometer sizes and water solubility. Mechanoluminescent materials convert focused ultrasound into light emission.”
X. Wu, Y. Jiang, N. J. Rommelfanger, F. Yang, Q. Zhou, J. Liu, W. Ren, S. Cai, A. Shin, K. S. Ong, K. Pu and G. Hong, “Tether-free photothermal deep-brain stimulation in freely behaving mice via widefield illumination in the near-infrared II window,” Nat. Biomed. Eng. 2022, DOI: 10.1038/s41551-022-00862-w
S. Jiang, X. Wu, N. J. Rommelfanger, Z. Ou, and G. Hong, “Shedding light on neurons: optical approaches for neuromodulation,” Natl. Sci. Rev. 2022, DOI: 10.1093/nsr/nwac007