Neural correlates of action
Cortical relation to muscle activity
Cortical prosthetics
Others: *Engineered Learning *Tuning function stability *Information estimation *Sensory replacement
“As a systems neurophysiology lab, we are interested in the way neural activity drives behavior. Our goal is to describe organizational principles of the time-varying relation between the firing rates of neurons and the behavior this activity generates. Specifically, our research program centers on the relationship between cerebral cortical activity and arm movement. Over the last 25 years, we have found that there is a very good representation of the armis trajectory in the collective firing pattern of frontal cortical activity. This makes it possible to predict the detailed time course of arm, wrist and finger movement that contains many of the behavioral invariants that are characteristic of movement. Research projects in our laboratory are based on this dynamic representation of behavior. The parameter of time is fundamental in our consideration of movement. We have shown that movement generation takes place continuously the cortical prediction of trajectory precedes movement execution with a time interval that is dependent on the figural components of the hands path.”
Chandrasekaran S, Fifer M, Bickel S, Osborn L, Herrero J, Christie B, Xu J, Murphy RKJ, Singh S, Glasser MF, Collinger JL, Gaunt R, Mehta AD, Schwartz A, Bouton CEHistorical perspectives, challenges, and future directions of implantable brain-computer interfaces for sensorimotor applications Bioelectron Med. 7(1):14
Kennedy SD, Schwartz ABDistributed processing of movement signaling Proc Natl Acad Sci